BPI-TS1.5 Technical Specifications
Active Components
2-[(3-Dodecanamidopropyl)dimethylaminio]acetate (concentrate: 150,000ppm, RTU: 15,000ppm)
5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan) (concentrate: 15,000ppm, RTU: 1500ppm)
6-methyl-2H-1-benzopyran-2-one (concentrate: 5000ppm, RTU: 500ppm)
Directions
Concentrate: Dilute with fresh water at 10:1 for high risk areas or at 30:1 for low risk areas. Spray onto surface or non-abrasive cleaning cloth and spread evenly around the surface. If cleaning the outside of electronic equipment, spray onto cloth first to avoid seeping into the equipment.
Ready-To-Use (RTU): Ready to use as-is, may be diluted with water 1:1 or 2:1 for low traffic, low risk areas. Spray onto surface or non-abrasive cleaning cloth and spread evenly around the surface. If cleaning the outside of electronic equipment, spray onto cloth first to avoid seeping into the equipment.
Warnings: IF SWALLOWED, CALL AUSTRALIA POISONS HOTLINE 131126
Keep out of reach of children. Do not spray onto food.
Overview
V-Shield Surface Sanitiser (primary active: BPI-TS1.5) is an alcohol-free, ammonia-free, water-based highly effective sanitisier designed specifically to be safe and non-abrasive for surfaces sensitive to damage from many other commercial cleaners. This sanitiser is able to be used on painted surfaces, glass, plastics, the exterior of electronic equipment and any other surfaces and finishes which may be at risk of being damaged by sanitisers such as ethanol/alcohol or bleaches.
V-Shield Surface Sanitiser contains BPI-TS1.5 (base formlation), consisting of three primary active sanitising compounds, conferring a broad range of activity against germs. These include 2-[(3-Dodecanamidopropyl)dimethylaminio]acetate (a quaternary ammonium disinfectant compound made from the oil of coconuts), 5-chloro-2-(2,4-dichlorophenoxy)phenol (triclosan), and 6-methyl-2H-1-benzopyran-2-one (derivative of bactericidal compounds from various berries).
Application
For regular surfaces: Dilute according to instructions on package, for concentrate dilute 10:1 (for high-risk areas, 10 parts water, 1 part sanitiser) or up to 30:1 (for low risk areas, 30 parts water, 1 part sanitiser), and for ready-to-use either use undiluted (equivalent to 10:1 dilution) or dilute maximum 2:1 (1 part water, 1 part sanitiser). Spray directly onto the surface or onto a non-abrasive cloth and rub into surface until dry, making sure to cover surface thoroughly to ensure full contact area. If sprayed onto food preparation surfaces, make sure to dry thoroughly before preparing food, and do not spray directly onto food. This is a foaming sanitiser, which will assist to maximise contact area, and foam will subside after being evenly spread.
For sensitive surfaces/equipment: Follow directions as above, but apply solution to cleaning cloth rather than directly to surface to ensure that the solution does not seep into any interior part of the equipment, to avoid damage to electronics etc. This sort of surface includes sensitive plastics, chairs/armrests, buttons/bezels, printed surfaces including artwork and decals, screens/displays, painted metals/plastics, keypads/keyboards, various solvent-sensitive finishes etc.
Test Results
Our primary concentrate formulation (BPI-TS1.5) was tested for activity against the coronavirus Murine Hepatitis Virus (MHV1), the industry gold-standard surrogate for SARS-Cov (www.tga.gov.au/surrogate-viruses-use-disinfectant-efficacy-tests-justify-claims-against-covid-19). The Log10 reduction of virus titre after 60 seconds achieved was 4.27. By comparison, 70% ethanol has a Log10 reduction of around 3.9 for the same virus and exposure time (Hulkower, Casanova, Rutala, Weber, & Sobsey, 2011). Log10 reduction of 4.27 is equivalent to inactivation of 99.995% of virus as per the equivalence formula % = 100%*(1-(10^-4.27)).
Formulation
Cleaning solutions based on ethanol, isopropyl alcohol, bleaches (sodium hypochlorite, hydrogen peroxide, ammonia) and turpentine are all effective disinfectants, however are unsuitable for applications on surfaces sensitive to degradation such as some plastics, screens, painted metals and other components commonly present within commercial premises. Many commonly available water-based/aqueous disinfectants which would normally be safe and suitable for these applications such as benzalkonium chloride and chlorhexidine suffer from being almost completely ineffective against coronaviruses (Kampf et. al, 2020).
However, a 0.05% solution or greater of triclosan has been demonstrated in the literature to have a log10 reduction factor of more than 4.34 (reduction of activity to 1/22,000th) when tested against Murine Hepatitis Virus, the TGA SARS-Cov surrogate (www.tga.gov.au/surrogate-viruses-use-disinfectant-efficacy-tests-justify-claims-against-covid-19), making it at least as effective as an 80% ethanol solution according to a paper from the Association for Professionals in Infection Control and Epidemiology (Dellanno, Vega, & Boesenberg, 2009). This result is supported by our results outlined in the section titled ‘Test Results’ above. Furthermore, aqueous triclosan is demonstrably safe for most surfaces, considering it is currently impregnated into various plastics, fabrics, cotton and cosmetic products (Braid, & Wale, 2002; Rodrigues, Teixeira, Oliveira, & Azeredo, 2011; Swofford, 2001; Zhang, Guo, Jin, Yin, & Zhu, 2007). As compared to alcohols and bleaches, aqueous triclosan is safe for appearance, colouration and structural integrity of the materials and coatings. In regards to other pathogens, “Triclosan has demonstrated immediate, persistent, broad-spectrum antimicrobial effectiveness and utility” (Jones, Jampani, Newman, & Lee, 2000). 2-[(3-Dodecanamidopropyl)dimethylaminio]acetate has demonstrated antimicrobial activity alone, but is particularly synergistic when combined with other disinfectants (Krasowska, Biegalska, & Łukaszewicz, 2012), and 6-methyl-2H-1-benzopyran-2-one has demonstrated broad antibacterial activity with the capability to both inhibit growth and destroy pathogenic bacteria (de Souza, Delle Monache, & Smânia, 2005).
Literature Reference
Braid, J. J., & Wale, M. C. (2002). The antibacterial activity of triclosan-impregnated storage boxes against Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus and Shewanella putrefaciens in conditions simulating domestic use. Journal of Antimicrobial Chemotherapy, 49(1), 87-94.
Dellanno, C., Vega, Q., & Boesenberg, D. (2009). The antiviral action of common household disinfectants and antiseptics against murine hepatitis virus, a potential surrogate for SARS coronavirus. American journal of infection control, 37(8), 649-652.
Hulkower, R. L., Casanova, L. M., Rutala, W. A., Weber, D. J., & Sobsey, M. D. (2011). Inactivation of surrogate coronaviruses on hard surfaces by health care germicides. American journal of infection control, 39(5), 401-407.
Jones, R. D., Jampani, H. B., Newman, J. L., & Lee, A. S. (2000). Triclosan: a review of effectiveness and safety in health care settings. American journal of infection control, 28(2), 184-196.
Kampf, G., Todt, D., Pfaender, S., & Steinmann, E. (2020). Persistence of coronaviruses on inanimate surfaces and their inactivation with biocidal agents. Journal of Hospital Infection, 104(3), 246-251.
Krasowska, A., Biegalska, A., & Łukaszewicz, M. (2012). Comparison of antimicrobial activity of three commercially used quaternary ammonium surfactants. Sepsis, 5(5), 170-174.
Rodrigues, D., Teixeira, P., Oliveira, R., & Azeredo, J. (2011). Salmonella enterica Enteritidis biofilm formation and viability on regular and triclosan-impregnated bench cover materials. Journal of food protection, 74(1), 32-37.
de Souza, S. M., Delle Monache, F., & Smânia, A. (2005). Antibacterial activity of coumarins. Zeitschrift fuer Naturforschung C, 60(9-10), 693-700.
Swofford, H. W. (2001). Antibacterial efficacy of polymers containing triclosan and other antimicrobial additives. American journal of infection control, 29(6), 428-429.
Zhang, B. H., Guo, Y. L., Jin, Y., Yin, Z. J., & Zhu, Q. (2007). Study of the application of triclosan in antibacterial finishing of cotton fabric [J]. Progress in Textile Science & Technology, 1(003).