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B-7251 Thermostim: Healthy Metabolism

Overview:

  • Activates cold-sensing TRPM8 receptors to ‘trick’ the body into increasing temperature via thermogenic fat burning (causes warmth)

  • Induces uncoupling protein recruitment in white & brown fat, enhancing fat metabolism

 

Duration:

5 hours

 

Ingredients:

Vegetable glycerine, (1R*,2S*)-N-(4-Methoxyphenyl)-5-methyl-2-(1-methylethyl) cyclohexane carboxamide 25 mg, 1,4-Dioxacycloheptadecane-5,17-dione 25mg, bioactive flavours     

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Application:

1ml in beverage daily in the morning, such as a smoothie or juice

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Legal Status:

Legal in Australia, food additive FEMA

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Description:

B-7251 contains a musk compound with activity at the PPAR alpha receptor, which is involved in maintenance of healthy tissue and wound repair. This receptor has also been implicated in control of lipid levels, by supporting healthy fat oxidation and metabolism and protecting natural defence against the negative cardiovascular effects of cholesterol. B-7251 also contains a 'cooling compound' which acts at the cold sensing receptor TRPM8. This receptor is a putative androgen receptor with significant androgen receptor interactions, protecting natural defence against the negative effects of androgens. Further, TRPM8 activation increases thermogenesis and uncoupling in adipose tissue, shifting from a white 'storing' fat phenotype to brown 'burning' fat phenotype, further enhancing maintenance of a healthy weight.

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1) Pereira-Fernandes, A., Vanparys, C., Vergauwen, L., Knapen, D., Jorens, P.G., & Blurst, R. (2014). Toxicogenomics in the 3T3-L1 cell line, a new approach for screening of obesogenic compounds. Toxicological Sciences, 140(2), 352-363.

2) Kim, S.H., Nam, G.W., Lee, H.K., Moon, S.J., & Chang, I.S. (2006). The effects of Musk T. on peroxisome proliferator-activated receptor [PPAR]-α activation, epidermal skin homeostasis and dermal hyaluronic acid synthesis. Archives of dermatological research, 298(6), 273-282.

3) Michalik, L., & Wahli, W. (2006) Involvement of PPAR nuclear receptors in tissue injury and wound repair. The journal of clinical investigation, 116(3), 598-606.

4) Tyagi, S., Gupta, P., Saini, A.S., Kaushal, C., & Sharma, S. (2011) The peroxisome proliferator-activated receptor: a family of nuclear receptors roles in various diseases. Journal of advanced pharmaceutical technology & research, 2(4), 236.

5) Rigamonti, E., Chinetti-Gbaguidi, G., & Staels, B. (2008). Regulation of macrophage functions by PPAR-α, PPAR-ỿ, AND LXRs in mice and men. Arteriosclerosis, thrombosis, and vascular biology, 28(6), 1050-1059.

6) Lefebvre, P., Chinetti, G., Fruchart, J.C., & Staels, B. (2006). Sorting out the roles of PPARα in energy metabolism and vascular homeostasis. The Journal of Clinical Investigation, 116(3), 571-580.

7) Asuthkar, S., Elustondo, P.A., Demirkhanyan, L., Sun, X., Baskaran, P., Velpula, K.K., & Zakharian, E. (2015). The TRPM8 Protein is a Testosterone receptor I. BIOCHEMICAL EVIDENCE FOR DIRECT TRPM8-TESTOSTERONE INTERACTIONS. Journal of Biological Chemistry, 290(5), 2659-2669.

8) Bidaux, G., Roudbaraki, M., Merle, C., Crepin, A., Delcourt, P., Slomianny, C., & Mauroy, B. (2005). Evidence for specific TRPM8 expression in human prostate secretory epithelial cells: functional androgen receptor requirement. Endocrine-related cancer, 12(2), 367-382

9) Asuthkar, S., Demirkhanyan, L., Sun, X., Elustondo, P.A., Krishnan, V., Baskaran, P., & Zakharian, E. (2015). The TRPM8 protein is a testosterone receptor II. FUNCTIONAL EVIDENCE FOR AN IONOTROPIC EFFECT OF TESTOSTERONE ON TRPM8. Journal of Biological Chemistry, 290(5), 2670-2688.

10) Zhang, L., & Barritt, G.J. (2006). TRPM8 in prostate cancer cells: a potential diagnostic and prognostic marker with a secretory function? Endocrine-Related Cancer, 13(1), 27-38.

11) Yee, N.S., Zhou, W., & Lee, M. (2010). Transient receptor potential channel TRPM8 is over expressed and required for cellular proliferation in pancreatic adenocarcinoma. Cancer letters, 297(1), 49-55.

12) Bai, V.U., Murthy, S., Chinnakannu, K., Muhletaler, F., Tejwani, S., Barrack, E.R., & Reddy, G. (2010). Androgen regulated TRPM8 expression: a potential m RNA marker for metastatic prostate cancer detection in body fluids. International Journal of oncology, 36(2), 443-450.

13) Moraes, M.N., de Assis, L.V.M., dos Santos Henriques, F., Batista Jr, M.L., Guler, A.D., & de Lauro Castrucci, A.M. (2017). Cold sensing TRPM8 channel participates in circadian control of the brown adipose tissue. Biochimica et Biophysica Acta (BBA) -Molecular cell research, 1864(12), 2415-2427.

14) Leffingwell, J.C. (2007). Cool without Menthol & Cooler than menthol and cooling compounds as insect repellents. From the internet: URL: http://www.leffingwell.com/cooler-than -menthol.htm [updated Apr.5,2006]

15) Chen, S., (2016). Light Dependant regulation of Sleep/Wake states by Prokineticin 2 in Larval Zebrafish (Doctoral dissertation, California Institute of Technology).

16) Buhr, E.D., (2008). Differential effects of physiological temperature changes on central versus peripheral circadian clocks in mice (Doctoral dissertation, Northwestern University).

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